Journal article
Childhood trauma relates to worse memory functioning in bipolar disorder
TJ Ehrlich, H Kim, KA Ryan, SA Langenecker, ER Duval, AK Yocum, C Diaz-Byrd, AL Wrobel, OM Dean, SM Cotton, M Berk, MG McInnis, DF Marshall
Journal of Affective Disorders | ELSEVIER | Published : 2023
Abstract
Background: Childhood trauma is commonly experienced by individuals diagnosed with bipolar disorder (BP). In BP, childhood trauma is related to a more severe clinical course, but its association with cognition remains unclear. Methods: This study evaluated 405 adult participants diagnosed with BP and 136 controls. Participants completed the Childhood Trauma Questionnaire and a comprehensive neuropsychological battery. High versus low childhood trauma was defined with one standard deviation above the control participant's mean Childhood Trauma Questionnaire score. Neuropsychological data was transformed into eight cognitive factors, including four executive functioning, auditory and visual me..
View full abstractGrants
Awarded by Brain and Behavior Research Foundation
Funding Acknowledgements
This research was supported by the Heinz C Prechter Bipolar Fund at the University of Michigan Depression Center and the Richard Tam Foundation. With gratitude, we acknowledge The University of Michigan Prechter Bipolar Longitudinal Participants and thank the research team lead by Dr. Melvin G. McInnis in the collection, stewardship and sharing of the data used in this publication. Data are available via request at prechter-data-request@med.umich.edu conditional on Data Use Agreement or contacting Melvin McInnis, MD at the following email address: mmcinnis@umich.edu. SMC is supported by National Health and Medical Research Council (NHMRC) Senior Research Fellowship (APP1136344) . MB is supported by a NHMRC Senior Principal Research Fellowship (1156072) .